Antineoplastic drugs are critical for cancer treatment, but their lack of specificity can kill not only cancer cells but also healthy cells. Another challenge for cancer treatment is the development of drug resistance, making drugs ineffective. A study in Scientific Reports shows the development of a smart drug delivery system using nanotechnology that can specifically deliver antineoplastic drugs to tumors in Balb/c mice. This approach effectively treated breast cancer in mice using a substantially smaller dosage compared to free Docetaxel (DTX). These nanoparticles not only were more cytotoxic to cancer cells but also significantly reduced metastasis compared to free drugs. These results show a promising alternative way to deliver cancer drugs. Using this smart drug delivery system can create more effective therapeutics with fewer side effects, allowing better cancer treatments.

Original reference: Taghipour, Y.D. et al. Sci. Rep. 14, 24603 (2024)

抗肿瘤药物对于癌症治疗至关重要，但它们缺乏特异性不仅可以杀死癌细胞，还可以杀死健康细胞。癌症治疗的另一个挑战是耐药性的发展，使药物无效。Scientific Reports 上的一项研究表明，使用纳米技术开发了一种智能药物递送系统，该系统可以特异性地将抗肿瘤药物递送到 Balb/c 小鼠的肿瘤中。与游离多西他赛 （DTX） 相比，这种方法使用小得多的剂量有效地治疗了小鼠的乳腺癌。与游离药物相比，这些纳米颗粒不仅对癌细胞更具细胞毒性，而且显着减少了转移。这些结果显示了一种有前途的癌症药物递送替代方法。使用这种智能药物输送系统可以创造更有效、副作用更少的治疗方法，从而实现更好的癌症治疗。

原始参考资料：Taghipour， Y.D. et al. Sci. Rep.14， 24603 （2024）