NADH Analogues Enable Metal- and Light-Free Decarboxylative Functionalization,Angewandte Chemie International Edition

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NADH Analogues Enable Metal- and Light-Free Decarboxylative Functionalization
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-11-25 , DOI: 10.1002/anie.202415131
Lei Liang _{1,

2} , Yue-Hui Wang ₁ , Cheng-Xing Cui ₁ , Xiao-Shan Deng ₁ , Song-Lin Wang ₁ , Hai-Ming Guo ₂ , Yingzi Li ₃ , Hong-Ying Niu ₁ , Runze Mao _{4,

5}

Affiliation

Here we report reduced nicotinamide adenine dinucleotide (NADH) analogs that enable metal- and light-free decarboxylative functionalization of RAEs under ambient and open-air conditions. This approach offers simple operation without inert gas protection, metals and light, rapid reaction completion within 5 minutes from the easily preparation of aryliodine (III) dicarboxylates, diverse bond formation (C−S, C−Se, C−SCF₃, C−C and C−CN bonds), broad substrate scope (>70 examples), and synthetic utility in late-stage functionalization, making this strategy complement classical decarboxylative strategies.

中文翻译：

NADH 类似物可实现无金属和无光的脱羧功能化

在这里，我们报道了还原的烟酰胺腺嘌呤二核苷酸（NADH）类似物，这些类似物能够在环境和露天条件下实现 RAE 的无金属和无光脱羧官能化。这种方法操作简单，无需惰性气体保护、金属和轻，从轻松制备芳基二羧（III）开始，在 5 分钟内快速完成反应，形成多种键（C-S、C-Se、C-SCF₃、C-C 和 C-CN 键），广泛的底物范围（>70 示例）和后期官能化中的合成效用，使该策略补充了经典的脱羧策略。

更新日期：2024-11-25

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