The controlled release of drugs remains a huge challenge in the field of tissue engineering. Current research focuses on the construction of drug carriers by using various advanced technologies. However, the pore-like structure that exists within our human body is ignored. Herein, a dental particle loaded with FTY720 by using dentin tubules (Dent-FTY720) was successfully prepared, which could achieve long-term sustained release of drugs. Meanwhile, Dent-FTY720 significantly promoted bone defect repair because of the similarity in composition to bone including hydroxyapatite and collagen. Furthermore, the loaded drugs exhibited both anti-immune and anti-inflammatory properties. This research introduces a novel concept in drug loading, highlighting the potential of dentin tubules as a drug delivery system.

中文翻译：

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牙本质小管作为长期缓释载体，通过加载 FTY720 加速骨骼修复


药物的控释仍然是组织工程领域的巨大挑战。目前的研究重点是利用各种先进技术构建药物载体。然而，我们人体内存在的孔状结构却被忽视了。在此，利用牙本质小管成功制备了负载 FTY720 的牙科颗粒 （Dent-FTY720），可实现药物的长期缓释。同时，Dent-FTY720 显着促进骨缺损修复，因为其成分与骨骼相似，包括羟基磷灰石和胶原蛋白。此外，负载的药物表现出抗免疫和抗炎特性。这项研究引入了一种新的载药概念，突出了牙本质小管作为药物递送系统的潜力。