Non-essential amino acids are often overlooked in biomedical research; however, they are crucial components of organismal metabolism. One such metabolite that is integral to physiological function is serine. Serine acts as a pivotal link connecting glycolysis with one-carbon and lipid metabolism, as well as with pyruvate and glutathione syntheses. Interestingly, increasing evidence suggests that serine metabolism may impact the aging process, and supplementation with serine may confer benefits in safeguarding against aging and age-related disorders. This review synthesizes recent insights into the regulation of serine metabolism during aging and its potential to promote healthy lifespan and mitigate a spectrum of age-related diseases.

非必需氨基酸在生物医学研究中经常被忽视;然而，它们是生物体代谢的关键组成部分。丝氨酸是生理功能不可或缺的一种代谢物。丝氨酸是连接糖酵解与一碳和脂质代谢以及丙酮酸和谷胱甘肽合成的关键环节。有趣的是，越来越多的证据表明，丝氨酸代谢可能会影响衰老过程，补充丝氨酸可能有助于防止衰老和与年龄相关的疾病。本综述综合了对衰老过程中丝氨酸代谢调节及其促进健康寿命和减轻一系列与年龄相关的疾病的潜力的最新见解。