ImportanceSeveral psychiatric disorders have been found to occur more frequently in persons with epilepsy (PWE) than in persons without epilepsy.ObjectiveTo summarize the prevalence of 20 psychiatric disorders in PWE compared with persons without epilepsy.Data SourcesThe search included records from inception to February 2024 in Ovid, MEDLINE, Embase, and PsycINFO.Study SelectionPublished epidemiological studies examining the prevalence of psychiatric disorders among PWE compared with persons without epilepsy were systematically reviewed. There were no restrictions on language or publication date.Data Extraction and SynthesisAbstracts were reviewed in duplicate, and data were extracted using a standardized electronic form. Descriptive statistics and meta-analyses are presented.Main Outcomes and MeasuresData were recorded on the prevalence of 20 psychiatric disorders among PWE compared with persons without epilepsy. Meta-analyses were performed along with descriptive analyses.ResultsThe systematic search identified 10 392 studies, 27 of which met eligibility criteria. The meta-analyses included 565 443 PWE and 13 434 208 persons without epilepsy. The odds of most psychiatric disorders studied were significantly increased in PWE compared with those without epilepsy, including anxiety (odds ratio [OR], 2.11; 95% CI, 1.73-2.58); depression (OR, 2.45; 95% CI, 1.94-3.09); bipolar disorder (OR, 3.12; 95% CI, 2.23-4.36); suicidal ideation (OR, 2.25; 95% CI, 1.75-2.88) but not suicide attempt (OR, 3.17; 95% CI, 0.49-20.46); psychotic disorder (OR, 3.98; 95% CI, 2.57-6.15); schizophrenia (OR, 3.72; 95% CI, 2.44-5.67); obsessive-compulsive disorder (OR, 2.71; 95% CI, 1.76-4.15); posttraumatic stress disorder (OR, 1.76; 95% CI, 1.14-2.73); eating disorders (OR, 1.87; 95% CI, 1.73-2.01); alcohol misuse (OR, 3.64; 95% CI, 2.27-5.83) and alcohol dependence (OR, 4.94; 95% CI, 3.50-6.96) but not alcohol abuse (OR, 2.10; 95% CI, 0.60-7.37); substance use disorder (OR, 2.75; 95% CI, 1.61-4.72); autism spectrum disorder (OR, 10.67; 95% CI, 6.35-17.91); and attention-deficit/hyperactivity disorder (OR, 3.93; 95% CI, 3.80-4.08).Conclusions and RelevanceIn this comprehensive study, most psychiatric comorbidities examined were significantly more prevalent in PWE than in those without epilepsy. These findings show the high burden of psychiatric comorbidities in PWE. This, in turn, underscores the need for appropriately identifying and treating psychiatric comorbidity in epilepsy to manage patients effectively and improve quality of life.

中文翻译：

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癫痫患者与非癫痫患者的精神合并症比较


重要性已发现几种精神疾病在癫痫患者 （PWE） 中比在非癫痫患者中更常见。目的总结与无癫痫患者相比，PWE 中 20 种精神疾病的患病率。数据来源该检索包括从建库到 2024 年 2 月在 Ovid、MEDLINE、Embase 和 PsycINFO 中的记录。对语言或出版日期没有限制。资料提取和综合摘要一式两份进行审查，并使用标准化的电子表格提取数据。介绍了描述性统计和荟萃分析。主要结局和测量 与无癫痫患者相比，PWE 中 20 种精神疾病患病率的数据。进行荟萃分析和描述性分析。结果系统检索确定了 10 392 项研究，其中 27 项符合纳入标准。荟萃分析包括 565 443 名 PWE 和 13 434 208 名无癫痫患者。与无癫痫的患者相比，PWE 研究的大多数精神疾病的几率显著增加，包括焦虑 （比值比 [OR]，2.11;95% CI，1.73-2.58）;抑郁 （OR， 2.45;95% CI， 1.94-3.09）;双相情感障碍 （OR， 3.12;95% CI， 2.23-4.36）;自杀意念 （OR， 2.25;95% CI， 1.75-2.88） 但未遂自杀 （OR， 3.17;95% CI， 0.49-20.46）;精神病 （OR， 3.98;95% CI， 2.57-6.15）;精神分裂症 （OR， 3.72;95% CI， 2.44-5.67）;强迫症 （OR， 2.71;95% CI， 1.76-4.15）;创伤后应激障碍 （OR， 1.76;95% CI， 1.14-2.73）;饮食失调 （OR， 1.87;95% CI， 1.73-2.01);酒精滥用 （OR， 3.64;95% CI， 2.27-5.83） 和酒精依赖 （OR， 4.94;95% CI， 3.50-6.96） 但不是酒精滥用 （OR， 2.10;95% CI， 0.60-7.37）;物质使用障碍 （OR， 2.75;95% CI， 1.61-4.72）;自闭症谱系障碍 （OR， 10.67;95% CI， 6.35-17.91）;和注意力缺陷/多动障碍 （OR，3.93;95% CI，3.80-4.08）。结论和相关性在这项综合研究中，所检查的大多数精神合并症在 PWE 中明显比没有癫痫的人更普遍。这些发现表明 PWE 的精神合并症负担很高。反过来，这强调了适当识别和治疗癫痫精神合并症的必要性，以有效管理患者并提高生活质量。