Glycopolymers are a versatile polymer type employed in many applications, especially the biomedical field, due to their ability to exploit multivalent lectin–carbohydrate interactions. Understanding how to improve and manipulate the interactions between glycopolymers and lectins is crucial for their success within the pharmaceutical industry. Herein, we synthesised block copolymers via cationic ring opening polymerisation of 2-ethyl-2-oxazoline and 2-(3-butenyl-2-oxazoline) with varying quantities of 2-ethyl-2-oxazoline. These polymers were further functionalised with pendent glucose moieties to produce glycopolymers. All polymers and glycopolymers were analysed using a variety of techniques including NMR, GPC, FT-IR and MALDI-ToF MS. Their binding capabilities were evaluated by surface plasmon resonance, utilising human lectins: DC-SIGN, MBL and Langerin, to investigate how the molar mass influences lectin binding.

中文翻译：

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聚（2-噁唑啉）基糖聚合物的摩尔质量对凝集素结合的影响


糖聚合物是一种用途广泛的聚合物类型，由于它们能够利用多价凝集素-碳水化合物相互作用，因此在许多应用中得到应用，尤其是生物医学领域。了解如何改善和操纵糖聚合物和凝集素之间的相互作用对于它们在制药行业的成功至关重要。在此，我们通过 2-乙基-2-噁唑啉和 2-（3-丁烯基-2-噁唑啉）与不同数量的 2-乙基-2-噁唑啉的阳离子开环聚合合成了嵌段共聚物。这些聚合物进一步用下垂的葡萄糖部分功能化以产生糖聚合物。使用包括 NMR、GPC、FT-IR 和 MALDI-ToF MS 在内的多种技术分析了所有聚合物和糖聚合物。通过表面等离子体共振评估它们的结合能力，利用人类凝集素：DC-SIGN、MBL 和 Langerin，以研究摩尔质量如何影响凝集素结合。