Crohn’s perianal fistula (CPF) is an aggressive phenotype of Crohn’s disease (CD) that remains challenging to diagnose and treat, with profound effects on quality of life (QOL). CPF affects approximately 25% of the 780,000 people in the United States living with CD.¹ Patients with CPF, only one-third of whom attain long-term remission,² have higher rates of hospitalizations, surgical intervention, and health care costs than those with isolated luminal CD, as well as significantly increased levels of morbidity, disability, and mental health deterioration. Compared with CD patients without CPF, they report worsened QOL, including overall well-being, friendships, relationships, social life, and career.

中文翻译：

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携手共进：实施多学科方法优化克罗恩病肛周瘘的诊断和管理


克罗恩病肛周瘘 （CPF） 是克罗恩病 （CD） 的一种侵袭性表型，诊断和治疗仍然具有挑战性，对生活质量 （QOL） 有深远影响。在美国 780,000 名 CD 患者中，约有 25% 患有 CPF。¹ CPF 患者，其中只有三分之一达到长期缓解，² 住院率、手术干预率和医疗保健费用高于孤立性管腔 CD 患者，并且发病率、残疾和心理健康恶化水平显着增加。与没有 CPF 的 CD 患者相比，他们报告的 QOL 恶化，包括整体幸福感、友谊、人际关系、社交生活和职业。