Diabetic foot ulcers are linked to a high disability rate, with no effective treatment currently available. Addressing infection, reducing oxidative stress, and safely managing chronic inflammation remain major challenges. In this study, a composite hydrogel dressing was developed using natural substances or clinically approved components (dopamine, D-alpha-tocopheryl polyethylene glycol succinate, and rhein). Upon near-infrared laser irradiation, the composite system rapidly heats and solidifies into a gel with photothermal antibacterial properties. Additionally, the decomposition of hydrogen peroxide releases oxygen, alleviating wound hypoxia. The hydrogel exhibited strong bactericidal activity against multiple bacterial strains. Without laser irradiation, the hydrogel effectively scavenged various free radicals and intracellular reactive oxygen species, restoring redox balance. Furthermore, it significantly reduced the expression of inflammatory cytokines, including interleukin-6 and interleukin-1β. In a diabetic mouse wound model infected with S. aureus, the mild photothermal therapy, combined with the antibacterial action of rhein, effectively managed bacterial infections, reduced inflammation, and promoted wound healing. Consequently, the photo-controlled therapeutic approach, offering antibacterial, antioxidant, and anti-inflammatory effects, holds promise for the effective treatment and management of infected diabetic wounds.

中文翻译：

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光控多功能水凝胶用于光热灭菌和改善感染糖尿病伤口的微环境


糖尿病足溃疡与高残疾率有关，目前尚无有效的治疗方法。解决感染问题、减少氧化应激和安全管理慢性炎症仍然是主要挑战。在这项研究中，使用天然物质或临床批准的成分（多巴胺、D-α-生育酚聚乙二醇琥珀酸酯和莱茵）开发了一种复合水凝胶敷料。在近红外激光照射下，复合系统迅速加热并固化成具有光热抗菌特性的凝胶。此外，过氧化氢的分解会释放氧气，缓解伤口缺氧。水凝胶对多种细菌菌株表现出很强的杀菌活性。在没有激光照射的情况下，水凝胶有效地清除了各种自由基和细胞内活性氧，恢复了氧化还原平衡。此外，它显著降低炎性细胞因子的表达，包括白细胞介素-6 和白细胞介素-1β。在感染金黄色葡萄球菌的糖尿病小鼠伤口模型中，温和的光热疗法结合大黄的抗菌作用，有效控制细菌感染，减少炎症，促进伤口愈合。因此，具有抗菌、抗氧化和抗炎作用的光控治疗方法有望有效治疗和管理感染的糖尿病伤口。