Biocompatible implants are essential for improving human health and longevity. Incorporating bioactive compounds, such as eugenol, into implant materials can improve biocompatibility and therapeutic efficacy. This study examines the effects of supercritical eugenol impregnation on the physical properties of 3D-printed polylactic acid samples produced by Fused Deposition Modeling. Impregnation was performed using a lab-scale high-pressure system, evaluating the impact of impregnation time on eugenol loading, distribution, and morphology. Fourier Transform Infrared spectroscopy confirmed homogeneous eugenol distribution with impregnation times exceeding 1 h, achieving loadings up to 12 wt%. Eugenol was released slowly over extended periods in a phosphate-buffered solution. Impregnated samples displayed more amorphous thermal behavior, with decreased Tg due to the plasticizing effect of the CO₂-eugenol mixture. Mechanical properties were slightly altered, with reduced stiffness and increased toughness. Microscopic deformations induced by impregnation could potentially enhance cellular adhesion, improving biocompatible material performance.

中文翻译：

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探索超临界二氧化碳在 3D 打印聚乳酸结构中丁香酚浸渍的潜力


生物相容性植入物对于改善人类健康和寿命至关重要。将生物活性化合物（如丁香酚）掺入植入材料中可以提高生物相容性和治疗效果。本研究研究了超临界丁香酚浸渍对熔融沉积建模生成的 3D 打印聚乳酸样品物理性能的影响。使用实验室规模的高压系统进行浸渍，评估浸渍时间对丁香酚负载、分布和形态的影响。傅里叶变换红外光谱证实了丁香酚分布均匀，浸渍时间超过 1 小时，负载量高达 12 wt%。丁香酚在磷酸盐缓冲溶液中长时间缓慢释放。浸渍样品表现出更多的无定形热行为，由于 CO₂-丁香酚混合物的塑化作用，Tg 降低。机械性能略有改变，刚度降低，韧性增加。浸渍引起的微观变形可能会增强细胞粘附，从而提高生物相容性材料的性能。