Ilex paraguariensis is a source of bioactive compounds, which have been demonstrated to mitigate neurological disorders and enhance athletic performance. This study aimed to decaffeinate yerba mate using supercritical fluid extraction, followed by caffeine purification. The purified extract was encapsulated in gelatin via spray drying, and its release profile was evaluated in simulated gastric fluid. A mathematical model was established to describe the release behavior of the encapsulated extract. The characterization of yerba mate leaves and extracts was conducted prior to and following purification via HPLC. The capsules were subjected to analysis using SEM, FTIR e TGA, while the release fluid was examined using ultraviolet spectroscopy. The optimized SFE process produced decaffeinated yerba mate and the resulting extract exhibited a caffeine purity of approximately 87 %. The capsules were observed to possess a spherical morphology and micrometric particle size, and the release profile was found to follow a first-order kinetic model.

中文翻译：

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马黛茶的超临界流体萃取：脱咖啡因、纯化、包封和控释


Ilex paraguariensis 是生物活性化合物的来源，已被证明可以减轻神经系统疾病并提高运动表现。本研究旨在通过超临界流体萃取对马黛茶进行脱咖啡因，然后进行咖啡因纯化。通过喷雾干燥将纯化的提取物封装在明胶中，并在模拟胃液中评估其释放曲线。建立了一个数学模型来描述封装提取物的释放行为。在 HPLC 纯化之前和之后对马黛茶叶和提取物进行表征。使用 SEM、FTIR 和 TGA 对胶囊进行分析，同时使用紫外光谱检查释放液。优化的 SFE 工艺生产了不含咖啡因的马黛茶，所得提取物的咖啡因纯度约为 87%。观察到胶囊具有球形形态和微米粒径，并且发现释放曲线遵循一级动力学模型。