Background Rising cancer incidence, particularly for colorectal cancer, has been reported in young adults. This study examined whether this is related to an increase in mortality. Methods We analysed World Health Organization (WHO) mortality data among young adults aged 25-49 in 15 most populous upper-middle and high-income countries from 1990 to 2021 with reliable data. Mid-year populations were retrieved from the United Nations for the American Countries and from the WHO for the other countries. We compared age-standardised mortality rates (ASMRs) in 2019-2021 to 2009-2011 and performed joinpoint regression analysis for all cancers and selected most common cancer sites: colorectum, pancreas, lung and breast. Results In 2019-2021, the highest ASMRs (per 100,000) were in Romanian males (38.6) and Argentinian females (45.9), while the lowest ones in Japan (males: 16.3; females: 22.7). ASMRs for colorectal cancers increased in 2019-2021 compared to 2009-2011 in nine countries among men and in seven countries among women. The highest increases were in the UK (males: +26.1%; females: +33.7%), Canada (males: +25.3%), and Mexico (males: +33.5%; females: +29.7%). Long-term analysis over the last three decades showed declining trends in total cancer mortality in the majority of countries, in lung cancer mortality across all countries, and in breast cancer in all countries except in Latin America. Conclusions While mortality from common cancers has generally decreased over the past three decades, mortality from colorectal cancer has increased in some countries. This highlights the need to control the obesity epidemic and implement targeted surveillance strategies in young populations.

中文翻译：

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15 个中高收入和高收入国家 50 岁以下癌症死亡率的趋势


背景 据报道，年轻人的癌症发病率不断上升，尤其是结直肠癌。本研究检查了这是否与死亡率增加有关。方法 我们分析了 1990 年至 2021 年人口最多的 15 个中高收入和高收入国家的 25-49 岁年轻人的世界卫生组织 （WHO） 死亡率数据，数据可靠。美洲国家从联合国检索了年中种群，其他国家从 WHO 检索了年中种群。我们比较了 2019-2021 年和 2009-2011 年的年龄标准化死亡率 （ASMR），并对所有癌症和选定的最常见癌症部位进行了连接点回归分析：结直肠、胰腺、肺和乳腺癌。结果 2019-2021 年，罗马尼亚男性 （38.6） 和阿根廷女性 （45.9） 的 ASMR（每 100,000 人）最高，而日本最低（男性：16.3;女性：22.7）。与 2009-2011 年相比，2019-2021 年在 9 个国家/地区的男性和 7 个国家/地区的女性中，结直肠癌的 ASMR 有所增加。增幅最高的是英国（男性：+26.1%;女性：+33.7%）、加拿大（男性：+25.3%）和墨西哥（男性：+33.5%;女性：+29.7%）。过去三十年的长期分析显示，大多数国家的癌症总死亡率、所有国家的肺癌死亡率以及除拉丁美洲以外的所有国家的乳腺癌死亡率呈下降趋势。结论 虽然在过去三十年中常见癌症的死亡率普遍下降，但结直肠癌的死亡率在一些国家有所增加。这凸显了控制肥胖流行病并在年轻人群中实施有针对性的监测策略的必要性。