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Advancing scalable and controllable multi-core droplet generation with double disturbance flow focusing.
Lab on a Chip ( IF 6.1 ) Pub Date : 2024-12-03 , DOI: 10.1039/d4lc00758a
Chen Li,Kai Mu,Fangsheng Huang,Zhiqiang Zhu,Ting Si

At present, a variety of active and passive methods for generating microdroplets with different morphologies are available. Microcapsules with multi-core or compartment structures not only exhibit characteristics such as encapsulation, isolation, and leak prevention, but also possess specific functions, including enhanced buffering performance and superior heat transfer characteristics. Nevertheless, the high-throughput manufacturing of controllable multi-core droplets remains a significant challenge, constrained by the complexity of the equipment, the inconvenience of control, and the high cost. This study introduces a novel flow focusing method that integrates biphasic excitation to produce uniformly distributed double-emulsion droplets with a controlled number of cores at high throughput. The breakup of coaxial jets has been studied under different excitation frequencies, amplitudes, and flow rates of inner and outer liquids, with a particular focus on the change of the droplet morphology as the controllable parameter varies. By applying excitation to both the inner and outer jets in the weak coupling mode, our technique exhibits promising outcomes in achieving uniformity and controllability in the number of cores of the generated droplets. The scaling laws of the compound droplet size have been obtained, providing theoretical guidance for practical applications. The proposed biphasic excitation approach enhances the precision and efficiency of droplet generation processes in a range of applications, including pharmaceuticals, biotechnology, and materials science.

中文翻译:


通过双重干扰流聚焦推进可扩展和可控的多核液滴生成。



目前,有多种主动和被动方法可用于生成具有不同形态的微滴。具有多核或隔室结构的微胶囊不仅具有封装、隔离和防漏等特性,而且还具有特定功能,包括增强的缓冲性能和卓越的传热特性。然而,受制于设备的复杂性、控制不便和高成本,可控多核液滴的高通量制造仍然是一个重大挑战。本研究介绍了一种新的流动聚焦方法,该方法集成了双相激发,以在高通量下产生具有受控核心数量的均匀分布的液液滴。已经研究了同轴射流在内部和外部液体的不同激发频率、振幅和流速下的变化,特别关注液滴形态随可控参数变化的变化。通过在弱耦合模式下对内部和外部射流施加激发,我们的技术在实现所生成液滴的芯数的均匀性和可控性方面取得了有希望的结果。得到了化合物液滴粒径的缩放规律,为实际应用提供了理论指导。所提出的双相激发方法提高了一系列应用(包括制药、生物技术和材料科学)中液滴生成过程的精度和效率。
更新日期:2024-11-22
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