The development of an intelligent nanomotor system holds great promise for enhancing the efficiency and effectiveness of antitumor therapy. Leveraging the overexpressed substances in the tumor microenvironment as propellants and chemotactic factors for enzyme-powered nanomotors represents a versatile and compelling approach. Herein, a plasma amine oxidase (PAO)-based chemotactic nanomotor system has been successfully developed, with the ability to enzymatically produce toxic acrolein and H2O2 from the upregulated polyamines (PAs) in the tumor microenvironment for active tumor therapy. Zwitterionic polymeric nanoparticles with superior biocompatibility are synthesized, followed by PAO modification via electrostatic interactions. As expected, the resulting nanomotor system exhibits positive chemotaxis toward PAs concentration gradient. Upon reaching the tumor region, our nanomotors, actuated by the tumor microenvironmental PAs, effectively enhance diffusion and enable deep penetration into the tumor site. This leads to the induction of tumor apoptosis and simultaneous inhibition of tumor invasion and migration by decomposing PAs into toxic products. By smartly utilizing the consumption of these local chemotactic factors and their enzymatic products, our nanomotor system provides a versatile and intelligent platform for active and enhanced tumor therapy.

中文翻译：

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具有趋化性的酶纳米马达用于基于产品的癌症治疗


智能纳米运动系统的开发对于提高抗肿瘤治疗的效率和效果具有很大的前景。利用肿瘤微环境中过表达的物质作为酶动力纳米马达的推进剂和趋化因子代表了一种通用且引人注目的方法。在此，已成功开发了一种基于血浆胺氧化酶 （PAO） 的趋化纳米运动系统，该系统能够从肿瘤微环境中上调的多胺 （PAs） 中酶促产生有毒的丙烯醛和 H 2 O 2 ，用于主动肿瘤治疗。合成了具有优异生物相容性的两性离子聚合物纳米颗粒，然后通过静电相互作用进行 PAO 改性。正如预期的那样，所得的纳米运动系统对 PAs 浓度梯度表现出正趋化性。到达肿瘤区域后，我们的纳米马达在肿瘤微环境 PA 的驱动下，有效地增强了扩散并能够深入渗透到肿瘤部位。这导致肿瘤凋亡的诱导，并通过将 PA 分解成有毒产物来同时抑制肿瘤侵袭和迁移。通过巧妙地利用这些局部趋化因子及其酶产物的消耗，我们的纳米运动系统为主动和增强的肿瘤治疗提供了一个多功能的智能平台。