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Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort
Blood ( IF 21.0 ) Pub Date : 2024-11-26 , DOI: 10.1182/blood.2024025738
Pierre-Edouard Debureaux, Stéphanie Poulain, Stéphanie Harel, Marie Passet, Marie Templé, Chloé Friedrich, Nathalie Forgeard, Dikelele Elessa, William Plas, Laureen Chat, Grégory Lazarian, Lise Willems, Bruno Royer, Alexis Talbot, Tristan Vaugeois, Floriane Theves, Alexandre Terré, Anne Brignier, Marion Malphettes, Daphné Krzisch, Laurent Frenzel, Frédéric Davi, Clotilde Bravetti, Florence Nguyen-Khac, Jehan Dupuis, Wendy Cuccuini, Didier Bouscary, Olivier Hermine, Damien Roos-Weil, Olivier Kosmider, Emmanuelle Clappier, Marion Espéli, Karl Balabanian, Bertrand Arnulf

Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of environmental cells to iWM.

中文翻译:


炎性 Waldenström 巨球蛋白血症与克隆性造血相关:一个多中心队列



Waldenström 巨球蛋白血症 (iWM) 的炎症形式可预测免疫化疗和布鲁顿酪氨酸激酶抑制剂后的结果,但其来源尚不清楚。在这里,我们揭示了 iWM 患者克隆造血功能增加 (61% vs 非炎症性 WM 中的 23%),表明环境细胞对 iWM 有贡献。
更新日期:2024-11-26
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