Lab Animal ( IF 5.9 ) Pub Date : 2024-11-22 , DOI: 10.1038/s41684-024-01459-3 Lauren A. Burgett, Theres B. Alexander, Haley A. Moya, Marcy A. Kingsbury
The translational value of the marble burying task (MBT) is debatable. Here we performed video analysis of behaviors during the MBT to accurately capture the details of all behaviors displayed during this task. Our results show that a count of marbles buried at the end of the task may not be a good translational correlate of the ‘intentional marble burying’ that the task is assumed to measure. Rather, the number of marbles buried may be measuring accidental marble burying due to ‘rapid digging’. Video analysis during MBT provides a novel approach to characterize the many behaviors displayed during this task and may explain inconsistencies reported in the literature. However, the number of marbles buried at the end of the MBT may still have value as a screening test for anxiogenic or anxiolytic interventions. Any interventions that show significant alterations in the number of marbles buried can be pursued further through more robust and comprehensive behavior scoring methods.
中文翻译:
大理石掩埋的修订版:大理石掩埋任务期间的视频分析对于了解啮齿动物的行为至关重要
大理石埋藏任务 (MBT) 的转化价值是有争议的。在这里,我们对 MBT 期间的行为进行了视频分析,以准确捕捉此任务期间显示的所有行为的详细信息。我们的结果表明,任务结束时埋设的弹珠数量可能与任务假定测量的 “故意埋葬弹珠 ”没有很好的转换相关性。相反,埋藏的弹珠数量可能衡量的是由于“快速挖掘”而导致的意外弹珠掩埋。MBT 期间的视频分析提供了一种新颖的方法来描述此任务期间显示的许多行为,并可能解释文献中报道的不一致之处。然而,埋在 MBT 末端的弹珠数量可能仍具有作为抗焦虑或抗焦虑干预的筛查试验的价值。任何显示埋藏弹珠数量发生显着变化的干预措施都可以通过更强大和全面的行为评分方法进一步进行。