We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared with interpretation based on variant allele fraction only.

中文翻译：

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甲基化测序增强了对克隆造血动力学的解释


我们开发了一种经济高效的 DNA 甲基化测序检测方法，以改善克隆性造血的监测。通过推断细胞类型比例，与仅基于变异等位基因分数的解释相比，该方法增强了对克隆轨迹的解释。