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Syntheses of some 2-hydroxypyrazine 1-oxides
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : May 1981 , DOI: 10.1002/jhet.5570180323
Akihiro Ohta , Sawako Masano , Mayumi Tsutsui , Fusako Yamamoto , Sumie Suzuki , Hiromi Makita , Hideo Tamamura , Yasuo Akita

A series of 2-hydroxypyrazine 1-oxides were prepared from the corresponding chloropyrazines by two methods, including oxidation processes in satisfactory yields. The treatment of 2,3-diphenylpyrazine 1,4-dioxide (6) led to 2,3-dichloro-5,6-diphenylpyrazine (7) and 2-chloro-5,6-diphenylpyrazine 1-oxide (8), and the latter was converted to 5,6-diphenyl-2-hydroxypyrazine 1-oxide (9) by an alkaline hydrolysis.

中文翻译:

某些2-羟基吡嗪1-氧化物的合成

由相应的氯吡嗪通过两种方法,包括以令人满意的产率进行的氧化方法,制备了一系列的2-羟基吡嗪1-氧化物。2,3-二苯基吡嗪1,4-二氧化物(6)的处理导致2,3-二氯-5,6-二苯基吡嗪(7)和2-氯-5,6-二苯基吡嗪1-氧化物(8),和后者通过碱水解转化为5,6-二苯基-2-羟基吡嗪1-氧化物(9)。
更新日期:2017-01-31
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