Chronic wasting disease (CWD) is an emerging disease in Europe. We report an increase in interspecies transmission capacity and zoonotic potential of a moose CWD isolate from Europe after passage in an ovine prion protein–expressing host. Those results indicated some CWD prions could acquire enhanced zoonotic properties following adaptation in an intermediate species.

中文翻译：

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中间物种适应后慢性消耗性疾病的人畜共患潜力

慢性消耗性疾病 （CWD） 是欧洲的一种新兴疾病。我们报道了来自欧洲的驼鹿 CWD 分离株在表达绵羊朊病毒蛋白的宿主中传代后，种间传播能力和人畜共患潜力增加。这些结果表明，一些 CWD 朊病毒在适应中间物种后可以获得增强的人畜共患特性。