Halogenation reactions are a vital area of study for the pharmaceutical industry. The study of the reaction conditions along with the reactors and their scale-up is a thrust area in drug synthesis and manufacturing. There is a shift in the research community towards accommodating renewable energy sources which has driven scientists to include energy sources that are sustainable and aid in making the overall process efficient. This review provides a comprehensive overview of the challenges in selecting the best catalyst, light source and reaction conditions for the fluorination, chlorination and bromination reactions. This paper goes a step further to explain the photoreactors’ design and modelling as well as the scale-up of the same. Overall, it provides a comprehensive view of diverse scientific areas, from halogenation in drug synthesis to the potential of photochemical batch and flow approaches in halogenation reactions.

中文翻译：

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全面深入地了解光辅助卤化反应：制药行业视角


卤化反应是制药行业的一个重要研究领域。研究反应条件以及反应器及其放大是药物合成和制造的一个重点领域。研究界正在转向容纳可再生能源，这促使科学家们纳入可持续且有助于提高整个过程效率的能源。本文全面概述了为氟化、氯化和溴化反应选择最佳催化剂、光源和反应条件所面临的挑战。本文进一步解释了光反应器的设计和建模以及它们的放大。总体而言，它提供了不同科学领域的全面视图，从药物合成中的卤化到卤化反应中光化学间歇和流动方法的潜力。