The palladium-catalyzed cross-coupling of (E)-2-fluoroallyl carbonates and allylboronates is reported. The regioselectivity is susceptive to the steric requirements of the NHC ligand, with small IMes favoring linear fluorinated 1,5-dienes, while IPr^BIDEA featuring sterically-congested character benefits branched products. Control experiments revealed that either 2-fluoroallyl carbonates or gem-F₂CPs could undergo allylation with excellent regioselectivity, yet the former showed somewhat lower branched reactivity.

中文翻译：

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钯催化的 NHC 配体控制的区域发散烯丙基-氟烯丙基交叉偶联


报道了 （E）-2-氟烯丙基碳酸酯和烯丙基硼酸盐的钯催化交叉偶联。区域选择性容易受到 NHC 配体的空间位阻要求的影响，小 IMe 有利于线性氟化 1,5-二烯，而具有空间充塞特性的 IPr^BIDEA 有利于支链产物。对照实验表明，2-氟烯丙基碳酸酯或 gem-F ₂CPs 可以以优异的区域选择性进行烯丙基化，但前者显示出略低的支链反应性。