Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered saturated cyclic amines into 7- and 8-membered aza-heterocycles can be achieved via a ring expansion cascade reaction.

中文翻译：

---

环胺扩环


由于合成的挑战，具有超过 6 个成员的环的 Aza 杂环在药物化学中的代表性不足。现在，可以通过扩环级联反应实现 5 元和 6 元饱和环胺转化为 7 元和 8 元氮杂环。