The pathological hallmarks of multiple system atrophy and Parkinson's disease are, respectively, misfolded-α-synuclein-laden glial cytoplasmic inclusions and Lewy bodies. CSF-soluble misfolded α-synuclein aggregates (seeds) are readily detected in people with Parkinson's disease by α-synuclein seed amplification assay (synSAA), but identification of seeds associated with multiple system atrophy for diagnostic purposes has proven elusive. We aimed to assess whether a novel synSAA could reliably distinguish seeds from Lewy bodies and glial cytoplasmic inclusions.

中文翻译：

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种子扩增测定诊断多系统萎缩的敏感性和特异性：一项多中心队列研究


多系统萎缩和帕金森病的病理标志分别是错误折叠的充满 α 突触核蛋白的神经胶质包涵体和路易体。CSF 可溶性错误折叠的 α-突触核蛋白聚集体（种子）很容易通过 α-突触核蛋白种子扩增测定 （synSAA） 在帕金森病患者中检测到，但事实证明，为诊断目的鉴定与多系统萎缩相关的种子已被证明难以捉摸。我们旨在评估一种新的 synSAA 是否可以可靠地区分种子与路易体和神经胶质细胞质包涵体。