The role of the vertebrate retina in early vision is generally described by the efficient coding hypothesis^1,2, which predicts that the retina reduces the redundancy inherent in natural scenes³ by discarding spatiotemporal correlations while preserving stimulus information⁴. It is unclear, however, whether the predicted decorrelation and redundancy reduction in the activity of ganglion cells, the retina’s output neurons, hold under gaze shifts, which dominate the dynamics of the natural visual input⁵. We show here that species-specific gaze patterns in natural stimuli can drive correlated spiking responses both in and across distinct types of ganglion cells in marmoset as well as mouse retina. These concerted responses disrupt redundancy reduction to signal fixation periods with locally high spatial contrast. Model-based analyses of ganglion cell responses to natural stimuli show that the observed response correlations follow from nonlinear pooling of ganglion cell inputs. Our results indicate cell-type-specific deviations from efficient coding in retinal processing of natural gaze shifts.

脊椎动物视网膜在早期视觉中的作用通常用有效编码假说^1,2 来描述，该假说预测视网膜通过丢弃时空相关性同时保留刺激信息⁴ 来减少自然场景³ 中固有的冗余。然而，目前尚不清楚预测的神经节细胞（视网膜的输出神经元）活动的去相关和冗余减少是否在注视移位下成立，而注视移位主导着自然视觉输入^{的动力学 5}。我们在这里表明，自然刺激中物种特异性的凝视模式可以驱动狨猴和小鼠视网膜中不同类型的神经节细胞内和之间的相关尖峰反应。这些协同响应破坏了冗余减少，以局部高空间对比度对信号固定周期进行缩减。基于模型的神经节细胞对自然刺激的反应分析表明，观察到的反应相关性来自神经节细胞输入的非线性池化。我们的结果表明，在自然凝视转移的视网膜处理中，细胞类型特异性与有效编码存在偏差。