Sulfur mustard (SM), a blister agent and toxic chemical warfare compound, leads to injuries in the skin, eyes, and lungs, with early diagnosis being difficult because of its incubation period. Developing scavengers for sulfur mustard (SM) and its simulant, 2-chloroethylsulfide (CEES), is essential due to the severe and long-lasting toxic effects these compounds have on the human body. Existing scavengers like cysteine, sodium hydrosulfide (NaHS), and sodium thiosulfate cannot cross the blood-brain barrier (BBB), rendering them ineffective for detoxifying SM in the brain and highlighting the need for lipophilic scavengers. In this study, an N-salicylaldehyde naphthyl thiourea probe (NCrHT) was developed for detecting SM simulant CEES and its in vivo and in vitro imaging capabilities were evaluated. Additionally, the detoxification potential of scavengers was tested under similar conditions, and we introduced N-acetyl cysteine, which is lipophilic in nature, as an effective scavenger for detoxifying CEES in the zebrafish brain.

中文翻译：

---

通过 N-水杨醛萘硫脲探针灵敏检测硫芥气中毒和解毒清除剂的研究


硫芥子气 （SM） 是一种泡罩剂和有毒化学战化合物，会导致皮肤、眼睛和肺部受伤，由于其潜伏期，早期诊断很困难。开发硫芥子气 （SM） 及其模拟物 2-氯乙基硫化物 （CEES） 的清除剂至关重要，因为这些化合物对人体具有严重而持久的毒性作用。现有的清除剂，如半胱氨酸、硫氢化钠 （NaHS） 和硫代硫酸钠不能穿过血脑屏障 （BBB），这使得它们无法有效解毒大脑中的 SM，并突出了对亲脂性清除剂的需求。在本研究中，开发了一种用于检测 SM 模拟 CEES 的 N-水杨醛萘硫脲探针 （NCrHT），并评价了其体内和体外成像能力。此外，在类似条件下测试了清道夫的解毒潜力，我们引入了本质上具有亲脂性的 N-乙酰半胱氨酸作为斑马鱼大脑中 CEES 解毒的有效清道夫。