We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

中文翻译：

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水中乳醇的同盟化


我们在生物相容性条件下开发了 3-羟基异苯并呋喃-1（3H）-酮和烯丙基硼酸盐的水促进交叉偶联。这种方法有助于以无金属方式合成多种 3-烯丙基邻苯二甲苯甲酸酯，产量高，选择性好。该方案的多功能性和实用性强调了其在药物化学中药物开发和应用的巨大潜力。