Optogenetics has emerged as a pivotal tool in neuroscience, enabling precise control of neural activity through light stimulation. However, the current microLED arrays lack sufficient density and scalability. This study proposes an innovative optogenetic device capable of integrating hundreds of microLEDs and electrocorticography (ECOG) electrodes. Individual or multiple microLEDs in the device can be selectively controlled with a custom controller. The light intensity of microLEDs decreases with increasing brain tissue penetration while maintaining a low temperature rise during pulse stimulations. In addition, interference from microLED pulses on ECOG electrode recordings could be alleviated with local mean subtraction data processing. The optogenetic device enables high-quality neural signal recording and triggers a significant enhancement in neural activity following light stimulation. Integration of microLED arrays and ECOG electrodes in the optogenetic device represents a promising advancement in neuroscientific research, providing improved spatial and temporal recording and control over neural activity.

中文翻译：

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用于神经刺激和记录的大规模、高密度 MicroLED 阵列光遗传学设备


光遗传学已成为神经科学的关键工具，能够通过光刺激精确控制神经活动。然而，目前的 microLED 阵列缺乏足够的密度和可扩展性。本研究提出了一种创新的光遗传学设备，能够集成数百个 microLED 和皮层电图 （ECOG） 电极。器件中的单个或多个 microLED 可以通过自定义控制器选择性地进行控制。microLED 的光强度随着脑组织穿透力的增加而降低，同时在脉冲刺激期间保持较低的温度升高。此外，可以通过局部平均减法数据处理来减轻 microLED 脉冲对 ECOG 电极记录的干扰。光遗传学设备能够实现高质量的神经信号记录，并在光刺激后触发神经活动的显着增强。将 microLED 阵列和 ECOG 电极集成到光遗传学设备中代表了神经科学研究的一个有前途的进步，提供了改进的空间和时间记录和对神经活动的控制。