The biological properties of antimicrobial peptides (AMPs) and amyloid proteins and their cross-talks have gained increasing attention due to their potential implications in both host defense mechanisms and amyloid-related diseases. However, complex interactions, molecular mechanisms, and physiological applications are not fully understood. The interplay between antimicrobial peptides and amyloid proteins is crucial for uncovering new insights into immune defense and disease mechanisms, bridging critical gaps in understanding infectious and neurodegenerative diseases. This review provides an overview of the cross-talk between AMPs and amyloids, highlighting their intricate interplay, mechanisms of action, and potential therapeutic implications. The dual roles of AMPs, which not only serve as key components of the innate immune system, combating microbial infections, but also exhibit modulatory effects on amyloid formation and toxicity, are discussed. The diverse mechanisms employed by AMPs to modulate amyloid aggregation, fibril formation, and toxicity are also discussed. Additionally, we explore emerging evidence suggesting that amyloid proteins may possess antimicrobial properties, adding a new dimension to the intricate relationship between AMPs and amyloids. This review underscores the importance of understanding the cross-talk between AMPs and amyloids to better understand the molecular processes underlying infectious diseases and amyloid-related disorders and to aid in the development of therapeutic avenues to treat them.

中文翻译：

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抗菌肽和淀粉样蛋白在宿主防御和疾病调节中的相互作用


抗菌肽 （AMPs） 和淀粉样蛋白的生物学特性及其串扰因其在宿主防御机制和淀粉样蛋白相关疾病中的潜在影响而受到越来越多的关注。然而，复杂的相互作用、分子机制和生理应用尚不完全清楚。抗菌肽和淀粉样蛋白之间的相互作用对于揭示免疫防御和疾病机制的新见解至关重要，可以弥合理解感染性和神经退行性疾病的关键差距。本综述概述了 AMPs 和淀粉样蛋白之间的串扰，强调了它们错综复杂的相互作用、作用机制和潜在的治疗意义。讨论了 AMP 的双重作用，它不仅作为先天免疫系统的关键组成部分，对抗微生物感染，而且还对淀粉样蛋白的形成和毒性表现出调节作用。还讨论了 AMP 用于调节淀粉样蛋白聚集、原纤维形成和毒性的不同机制。此外，我们探索了新出现的证据表明淀粉样蛋白可能具有抗菌特性，为 AMP 和淀粉样蛋白之间的复杂关系增加了一个新的维度。本综述强调了了解 AMP 和淀粉样蛋白之间的串扰的重要性，以更好地了解传染病和淀粉样蛋白相关疾病的分子过程，并帮助开发治疗途径。