The potential hazards of bisphenol A (BPA) to the environment have become a global concern. Herein, 2D Zn-based metal-organic framework nanosheet (2D Zn-MOF) and MnCO₃ nanocomposite (Zn-MOF-MnCO₃), an efficient electrochemiluminescence (ECL) probe was first synthesized and constructed for trace detection of BPA. Owing to the elimination of the aggregation-induced quenching (ACQ) effect of polycyclic aromatic hydrocarbons (PAHs), the leaf-like Zn-MOF exhibited a satisfactory ECL signal. The MnCO₃, which has excellent biocompatibility, showed excellent ECL efficiency in the presence of K₂S₂O₈. With the covalent binding of Zn-MOF and MnCO₃, we demonstrated that the ECL intensity and stability of Zn-MOF-MnCO₃ improved significantly. In addition, the inner filter effect (IFE) of Fe₃O₄-NH₂ NPs toward Zn-MOF-MnCO₃ had been confirmed to be the ECL quenching mechanism. Based on above strategies, the proposed ECL-IFE biosensor exhibited a trace detection ability of BPA in a wide linear range (10 fM ∼ 10 μM) with a low detection limit (4.2 fM). Further in-depth study confirmed the excellent repeatability, selectivity, and stability of sensors, which provided a fresh sensing platform for trace detection of BPA in the environment.

中文翻译：

---

二维锌基金属有机框架作为高效的电化学发光发射器：一种用于双酚 A 痕量检测的新型基于内滤效应的 ECL 生物传感器


双酚 A （BPA） 对环境的潜在危害已成为全球关注的问题。在此，首次合成并构建了 2D Zn 基金属有机框架纳米片 （2D Zn-MOF） 和 MnCO₃ 纳米复合材料 （Zn-MOF-MnCO₃），一种高效的电化学发光 （ECL） 探针，用于 BPA 的痕量检测。由于消除了多环芳烃 （PAHs） 的聚集诱导淬灭 （ACQ） 效应，叶状 Zn-MOF 表现出令人满意的 ECL 信号。MnCO₃ 具有优异的生物相容性，在 K₂S₂O₈ 存在下表现出优异的 ECL 效率。通过 Zn-MOF 和 MnCO₃ 的共价结合，我们证明 Zn-MOF-MnCO₃ 的 ECL 强度和稳定性显着提高。此外，Fe₃O_{4-NH 2} NPs 对 Zn-MOF-MnCO₃ 的内滤效应 （IFE） 已被证实是 ECL 猝灭机制。基于上述策略，所提出的 ECL-IFE 生物传感器在较宽的线性范围 （10 fM ∼ 10 μM） 内表现出 BPA 的痕量检测能力，检测限较低 （4.2 fM）。进一步的深入研究证实了传感器优异的重复性、选择性和稳定性，为环境中 BPA 的痕量检测提供了新的传感平台。