Epigenetic drugs have been used in the treatment of many diseases. Unfortunately, however, epigenetic drugs are not targeted, which makes the action of epigenetic drugs often systemic. This systemic epigenetic alteration can lead to a host of unwanted side effects. To improve delivery targeting and enhance the efficacy of drugs, the application of novel drug carriers in the field of epigenetic drug delivery becomes very important. We summarize the types of materials that have been used in the field of epigenetic drug delivery, such as liposomes, micelles, inorganic materials, framework materials, and so on (mainly in cancer therapy). We also describe some of the biocompatible or condition-responsive modifications commonly used in the field of drug nano-delivery based on the properties of different materials. Finally, we also draw inspiration from other drug delivery materials and reveal more materials that are still not used for epigenetic drug delivery, such as HOFs, Janus particles, molecular cage-like materials, etc., and discuss the current challenges and the way forward, which will provide more ideas for researchers.

中文翻译：

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材料观点：表观遗传药物纳米递送的现实和潜力


表观遗传药物已用于治疗许多疾病。然而，不幸的是，表观遗传药物不是靶向的，这使得表观遗传药物的作用通常是全身性的。这种系统性的表观遗传改变会导致许多不需要的副作用。为了提高递送靶向性并增强药物疗效，新型药物载体在表观遗传药物递送领域的应用变得非常重要。我们总结了表观遗传药物递送领域已使用的材料类型，如脂质体、胶束、无机材料、框架材料等（主要在癌症治疗中）。我们还根据不同材料的特性描述了药物纳米递送领域常用的一些生物相容性或条件响应性修饰。最后，我们还从其他药物递送材料中汲取灵感，揭示了更多仍未用于表观遗传药物递送的材料，如 HOFs、Janus 颗粒、分子笼状材料等，并讨论了当前的挑战和前进的道路，这将为研究人员提供更多思路。