Addressing the fragility of bioentities that results in instability and compromised performance during storage and applications, reticular chemistry, specifically through metal–organic frameworks (MOFs) and covalent organic frameworks (COFs), offers versatile platforms for stabilization and enhancement of bioentities. These highly porous frameworks facilitate efficient loading and mass transfer, offer confined environments and selective permeability for stabilization and protection, and enable finely tunable biointerfacial interactions and microenvironments for function optimization, significantly broadening the applications of various bioentities, including enzymes, nucleic acids, cells, etc. This Perspective outlines strategies for integrating bioentities with reticular frameworks, highlighting new design ideas for existing issues within these strategies. It emphasizes the crucial roles of these frameworks for bioentities in enhancing stability, boosting activity, imparting non-native functions, and synergizing bioentity systems. Concluding with a discussion of the challenges and prospects in the design, characterization, and practical applications of these biocomposites, this Perspective aims to inspire further development of high-performance biocomposites in this promising field.

中文翻译：

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用于增强生物实体稳定性和功能性能的网状化学


网状化学，特别是通过金属有机框架 （MOF） 和共价有机框架 （COF），解决了生物实体在储存和应用过程中导致不稳定和性能下降的脆弱性问题，为稳定和增强生物实体提供了多功能平台。这些高度多孔的框架有助于高效的加载和传质，提供密闭环境和选择性渗透性以实现稳定和保护，并实现精细可调的生物界面相互作用和微环境以实现功能优化，显着拓宽了各种生物实体的应用，包括酶、核酸、细胞等。本视角概述了将生物实体与网状框架相结合的策略，突出了这些策略中现有问题的新设计思路。它强调了这些框架对生物实体在增强稳定性、促进活动、赋予非原生功能和协同生物实体系统方面的关键作用。最后，本期文章讨论了这些生物复合材料的设计、表征和实际应用方面的挑战和前景，旨在激发高性能生物复合材料在这一前景广阔的领域的进一步发展。