Structural DNA nanotechnology enables the self‐organization of matter at the nanometer scale, but approaches to expand the inorganic and electrical functionality of these scaffolds remain limited. Developments in nucleic acid metallics have enabled the incorporation of site‐specific metal ions in DNA duplexes and provide a means of functionalizing the double helix with atomistic precision. Here a class of 2D DNA nanostructures that incorporate the cytosine‐Ag+‐cytosine (dC:Ag+:dC) base pair as a chemical trigger for self‐assembly is described. It is demonstrated that Ag+‐functionalized DNA can undergo programmable assembly into large arrays and rings, and can be further coassembled with guanine tetraplexes (G4). It is shown that 2D DNA lattices can be assembled with a variety of embedded nanowires at tunable spacing. These results serve as a foundation for further development of self‐assembled, metalated DNA nanostructures, with potential for high‐precision DNA nanoelectronics with nanometer pitch.

中文翻译：

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银 （I） 介导的 2D DNA 纳米结构


结构 DNA 纳米技术能够在纳米尺度上实现物质的自组织，但扩展这些支架的无机和电功能的方法仍然有限。核酸金属的发展使位点特异性金属离子能够掺入 DNA 双链体，并提供了一种以原子精度功能化双螺旋的方法。这里描述了一类 2D DNA 纳米结构，它们结合了胞嘧啶-Ag+-胞嘧啶 （dC：Ag+:d C） 碱基对作为自组装的化学触发器。结果表明，Ag+ 功能化 DNA 可以经过编程组装成大阵列和环，并且可以进一步与鸟嘌呤四链体 （G4） 共组装。结果表明，2D DNA 晶格可以以可调间距与各种嵌入的纳米线组装。这些结果为进一步开发自组装的金属化 DNA 纳米结构奠定了基础，具有纳米间距的高精度 DNA 纳米电子学的潜力。