InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences into families. It integrates predictive models, known as signatures, from multiple member databases to classify sequences into families and predict the presence of domains and significant sites. The InterPro database provides annotations for over 200 million sequences, ensuring extensive coverage of UniProtKB, the standard repository of protein sequences, and includes mappings to several other major resources, such as Gene Ontology (GO), Protein Data Bank in Europe (PDBe) and the AlphaFold Protein Structure Database. In this publication, we report on the status of InterPro (version 101.0), detailing new developments in the database, associated web interface and software. Notable updates include the increased integration of structures predicted by AlphaFold and the enhanced description of protein families using artificial intelligence. Over the past two years, more than 5000 new InterPro entries have been created. The InterPro website now offers access to 85 000 protein families and domains from its member databases and serves as a long-term archive for retired databases. InterPro data, software and tools are freely available.

中文翻译：

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InterPro：2025 年的蛋白质序列分类资源


InterPro （https://www.ebi.ac.uk/interpro） 是一种免费访问的资源，用于将蛋白质序列分类为家族。它集成了来自多个成员数据库的预测模型（称为签名），以将序列分类为系列并预测域和重要位点的存在。InterPro 数据库为超过 2 亿个序列提供注释，确保广泛覆盖蛋白质序列的标准存储库 UniProtKB，并包括与其他几个主要资源的映射，例如基因本体论 （GO）、欧洲蛋白质数据库 （PDBe） 和 AlphaFold 蛋白质结构数据库。在本出版物中，我们报告了 InterPro（101.0 版）的状态，详细介绍了数据库、相关 Web 界面和软件的新发展。值得注意的更新包括 AlphaFold 预测的结构的集成增加，以及使用人工智能增强对蛋白质家族的描述。在过去两年中，已经创建了 5000 多个新的 InterPro 条目。InterPro 网站现在提供对其成员数据库中 85 000 个蛋白质家族和结构域的访问，并作为已停用数据库的长期存档。InterPro 数据、软件和工具均可免费获得。