Pharmacogenomics, the study of how an individual's genetic makeup influences their response to medications, is a rapidly evolving field with significant implications for personalized medicine. As researchers and healthcare professionals face challenges in exploring the intricate relationships between genetic profiles and therapeutic outcomes, the demand for effective and user-friendly tools to access and analyze genetic data related to drug responses continues to grow. To address these challenges, we have developed PGxDB, an interactive, web-based platform specifically designed for comprehensive pharmacogenomics research. PGxDB enables the analysis across a wide range of genetic and drug response data types - informing cell-based validations and translational treatment strategies. We developed a pipeline that uniquely combines the relationship between medications indexed with Anatomical Therapeutic Chemical (ATC) codes with molecular target profiles with their genetic variability and predicted variant effects. This enables scientists from diverse backgrounds - including molecular scientists and clinicians - to link genetic variability to curated drug response variability and investigate indication or treatment associations in a single resource. With PGxDB, we aim to catalyze innovations in pharmacogenomics research, empower drug discovery, support clinical decision-making, and pave the way for more effective treatment regimens. PGxDB is a freely accessible database available at https://pgx-db.org/

中文翻译：

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PGxDB：用于药物基因组学研究的交互式 Web 平台


药物基因组学是研究个体基因组成如何影响他们对药物反应的领域，是一个快速发展的领域，对个性化医疗具有重大影响。随着研究人员和医疗保健专业人员在探索遗传图谱和治疗结果之间的复杂关系方面面临挑战，对有效且用户友好的工具来访问和分析与药物反应相关的遗传数据的需求不断增长。为了应对这些挑战，我们开发了 PGxDB，这是一个基于 Web 的交互式平台，专为全面的药物基因组学研究而设计。PGxDB 能够对各种遗传和药物反应数据类型进行分析，为基于细胞的验证和转化治疗策略提供信息。我们开发了一个管道，它独特地结合了用解剖治疗化学 （ATC） 代码索引的药物与分子靶标谱之间的关系，以及它们的遗传变异性和预测的变异效应。这使得来自不同背景的科学家（包括分子科学家和临床医生）能够将遗传变异性与精选的药物反应变异性联系起来，并在单一资源中研究适应症或治疗关联。通过 PGxDB，我们的目标是促进药物基因组学研究的创新，增强药物发现的能力，支持临床决策，并为更有效的治疗方案铺平道路。PGxDB 是一个可免费访问的数据库，可在 https://pgx-db.org/