BackgroundDeep brain stimulation is a treatment for advanced Parkinson's disease and currently tuned to target motor symptoms during daytime. Parkinson's disease is associated with multiple nocturnal symptoms such as akinesia, insomnia, and sleep fragmentation, which may require adjustments of stimulation during sleep for best treatment outcome.ObjectivesThere is a need for a robust biomarker to guide stimulation titration across sleep stages. This study aimed to investigate whether evoked resonant neural activity (ERNA) is modulated by sleep.MethodsWe recorded local field potentials from the subthalamic nucleus of four Parkinson's patients with externalized electrodes while applying single stimulation pulses to investigate the effect of sleep on ERNA.ResultsWe found that ERNA features change with wakefulness and sleep stages and are correlated with canonical frequency bands and heart rate.ConclusionsGiven that ERNA modulates with sleep, it could be used as a robust marker for automatic stimulation titration during sleep. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

中文翻译：

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丘脑底核中刺激诱发的共振神经活动受睡眠调节


背景深部脑刺激是一种针对晚期帕金森病的治疗方法，目前针对白天的运动症状进行了调整。帕金森病与多种夜间症状有关，例如运动不能、失眠和睡眠碎片化，这可能需要调整睡眠期间的刺激以获得最佳治疗效果。目标需要一种强大的生物标志物来指导整个睡眠阶段的刺激滴定。本研究旨在调查诱发共振神经活动 （ERNA） 是否受睡眠调节。方法我们用外化电极记录了 4 例帕金森病患者丘脑底核的局部场电位，同时应用单次刺激脉冲以研究睡眠对 ERNA 的影响。结果我们发现 ERNA 特征随觉醒和睡眠阶段而变化，并与典型频带和心率相关。结论鉴于 ERNA 随睡眠调节，它可以用作睡眠期间自动刺激滴定的可靠标志物。© 2024 作者。由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版的《运动障碍》。