Clinical trials and meta-analyses are considered high-level medical evidence with solid credibility. However, such clinical evidence for traditional Chinese medicine (TCM) is scattered, requiring a unified entrance to navigate all available evaluations on TCM therapies under modern standards. Besides, novel experimental evidence has continuously accumulated for TCM since the publication of HERB 1.0. Therefore, we updated the HERB database to integrate four types of evidence for TCM: (i) we curated 8558 clinical trials and 8032 meta-analyses information for TCM and extracted clear clinical conclusions for 1941 clinical trials and 593 meta-analyses with companion supporting papers. (ii) we updated experimental evidence for TCM, increased the number of high-throughput experiments to 2231, and curated references to 6 644. We newly added high-throughput experiments for 376 diseases and evaluated all pairwise similarities among TCM herbs/ingredients/formulae, modern drugs and diseases. (iii) we provide an automatic analyzing interface for users to upload their gene expression profiles and map them to our curated datasets. (iv) we built knowledge graph representations of HERB entities and relationships to retrieve TCM knowledge better. In summary, HERB 2.0 represents rich data type, content, utilization, and visualization improvements to support TCM research and guide modern drug discovery. It is accessible through http://herb.ac.cn/v2 or http://47.92.70.12.

中文翻译：

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HERB 2.0：整合中医临床和实验证据的更新数据库


临床试验和荟萃分析被认为是具有坚实可信度的高水平医学证据。然而，中医 （TCM） 的临床证据是分散的，需要一个统一的入口来浏览现代标准下所有可用的中医疗法评估。此外，自 HERB 1.0 发布以来，中医的新实验证据不断积累。因此，我们更新了 HERB 数据库以整合四种类型的中医证据：（i） 我们整理了 8558 项临床试验和 8032 项荟萃分析信息，并为 1941 项临床试验和 593 项荟萃分析提取了明确的临床结论，并附有配套支持论文。（ii） 我们更新了 TCM 的实验证据，将高通量实验的数量增加到 2231 个，并整理了 6 644 个参考文献。我们新增了 376 种疾病的高通量实验，并评估了中草药/成分/配方、现代药物和疾病之间的所有成对相似性。（iii） 我们为用户提供了一个自动分析界面，以上传他们的基因表达谱并将其映射到我们精选的数据集。（iv） 我们构建了 HERB 实体和关系的知识图谱表示，以更好地检索 TCM 知识。总之，HERB 2.0 代表了丰富的数据类型、内容、利用率和可视化改进，以支持中医研究并指导现代药物发现。可通过 http://herb.ac.cn/v2 或 http://47.92.70.12 访问。