The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection and use of small-molecule compounds that qualify as chemical probes. These high-quality reagents are essential for exploring the function of individual proteins in complex biological systems, such as cells and organisms, and for validating proteins as potential therapeutic targets. The use of reliable chemical probes accelerates protein annotation in basic biological studies and informs drug discovery. However, the use of low-quality compounds has historically led to erroneous conclusions in biomedical research, and experience shows that failure to follow best practice continues, an issue which the Portal aims to address. Here, we describe the latest updates to the Chemical Probes Portal in both content and functionality. The number of chemical probes and human protein targets covered has increased significantly, with improvements in the processes for obtaining expert reviews and user engagement. Moreover, new functionalities and enhanced tools have been introduced to better support biological researchers in selecting and using the best chemical probes for their studies.

中文翻译：

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化学探针门户 – 2024 年：更新此公共资源以支持生物医学研究中小分子的最佳实践选择和使用。


Chemical Probes Portal （www.chemicalprobes.org） 是一个基于专家评审的免费公共资源，支持评估、选择和使用符合化学探针条件的小分子化合物。这些高质量试剂对于探索复杂生物系统（如细胞和生物体）中单个蛋白质的功能以及验证蛋白质作为潜在治疗靶标至关重要。使用可靠的化学探针可加速基础生物学研究中的蛋白质注释，并为药物发现提供信息。然而，使用低质量化合物历来会导致生物医学研究得出错误的结论，经验表明，未能遵循最佳实践的情况仍然存在，这是该门户网站旨在解决的问题。在这里，我们介绍了 Chemical Probes Portal 在内容和功能方面的最新更新。随着获得专家评价和用户参与的流程得到改进，所涵盖的化学探针和人类蛋白质靶标的数量显著增加。此外，还引入了新功能和增强工具，以更好地支持生物研究人员选择和使用最佳化学探针进行研究。