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Cobalt-Catalyzed Regioselective C8–H Sulfoxamination of 1-Naphthylamine Derivatives with NH-Sulfoximines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2024-11-18 , DOI: 10.1021/acs.joc.4c02318 Nileshkumar B. Rathod, Raj N. Patel, Sachinkumar D. Patel, Dharmik M. Patel, Mahesh A. Sonawane, Dinesh Gopichand Thakur, Subhash Chandra Ghosh
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2024-11-18 , DOI: 10.1021/acs.joc.4c02318 Nileshkumar B. Rathod, Raj N. Patel, Sachinkumar D. Patel, Dharmik M. Patel, Mahesh A. Sonawane, Dinesh Gopichand Thakur, Subhash Chandra Ghosh
A simple cobalt-catalyzed, picolinamide-directed C8–H sulfoxamination of 1-naphthalamides with NH-sulfoximines has been developed. This cross-dehydrogenative C–H/N–H coupling reaction offers a facile route to N-arylated sulfoximines, exhibiting high yields, a broad substrate scope, and excellent functional group tolerance and scalability.
中文翻译:
钴催化的 1-萘胺衍生物与 NH-亚砜胺的区域选择性 C8–H 砜酰胺化
已经开发了一种简单的钴催化、吡啶甲酰胺定向的 1-萘酰胺与 NH-亚砜胺的 C8-H 磺胺化。这种交叉脱氢 C-H/N-H 偶联反应为 N-芳基化砜胺提供了一种简单的途径,表现出高产率、广泛的底物范围以及出色的官能团耐受性和可扩展性。
更新日期:2024-11-19
中文翻译:
钴催化的 1-萘胺衍生物与 NH-亚砜胺的区域选择性 C8–H 砜酰胺化
已经开发了一种简单的钴催化、吡啶甲酰胺定向的 1-萘酰胺与 NH-亚砜胺的 C8-H 磺胺化。这种交叉脱氢 C-H/N-H 偶联反应为 N-芳基化砜胺提供了一种简单的途径,表现出高产率、广泛的底物范围以及出色的官能团耐受性和可扩展性。