Chronic diabetes wound repairing is still a huge challenge in clinical practice. High concentration of reactive oxygen species and vascular disfunction are the main factors hindering the recovery of diabetes wounds. This research grafted betaine onto chitosan (CSBT) to enhance the antibacterial property and the CSBT was cross-linked with PEO₉₀ dialdehyde (PEO DA) to prepare hydrogel with Ca²⁺ loading to promote the coagulation. The polydopamine nanoparticles (PDA NPs) with photothermal property and antioxidant property was composited to the hydrogel and deferoxamine (DFO) was loaded to fabricate the multifunctional CBPCa/PDA/DFO hydrogel to promote vascular regeneration in combination with photothermal antibacterial performance for the diabetes wounds treatment. The CBPCa/PDA/DFO hydrogel showed good mechanical strength, injectability, anti-inflammatory property and coagulation performance. Furthermore, the antibacterial effect of chitosan based hydrogel was enhanced with near infrared (NIR) stimulated photothermal treatment. Combined with the photothermal effect and the angiogenic drug DFO release, the CBPCa/PDA/DFO hydrogel significantly enhanced vascular regeneration and reduced the inflammation in the in vivo wound repairing experiment. As a result, the CBPCa/PDA/DFO hydrogel may provide a promising therapeutic platform for diabetic trauma repairing.

中文翻译：

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抗菌甜菜碱改性壳聚糖基水凝胶，具有血管生成特性，用于光热增强糖尿病伤口修复


慢性糖尿病伤口修复在临床实践中仍然是一个巨大的挑战。高浓度的活性氧和血管功能障碍是阻碍糖尿病伤口恢复的主要因素。本研究将甜菜碱接枝到壳聚糖 （CSBT） 上以增强抗菌性能，并将 CSBT 与 PEO₉₀ 二醛 （PEO DA） 交联，制备具有 Ca²⁺ 负载的水凝胶以促进凝血。将具有光热性能和抗氧化性能的聚多巴胺纳米颗粒 （PDA NPs） 合成到水凝胶上，并加载去铁胺 （DFO） 制备多功能 CBPCa/PDA/DFO 水凝胶，以促进血管再生，结合光热抗菌性能治疗糖尿病伤口。CBPCa/PDA/DFO 水凝胶表现出良好的机械强度、注射性、抗炎性和凝血性能。此外，近红外 （NIR） 刺激光热处理增强了壳聚糖基水凝胶的抗菌效果。结合光热效应和血管生成药物 DFO 释放，CBPCa/PDA/DFO 水凝胶在体内伤口修复实验中显着增强血管再生并减轻炎症。因此，CBPCa/PDA/DFO 水凝胶可能为糖尿病创伤修复提供一个有前途的治疗平台。