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Progress in Organ Bioprinting for Regenerative Medicine
Engineering ( IF 10.1 ) Pub Date : 2024-06-14 , DOI: 10.1016/j.eng.2024.04.023
Xiang Wang, Di Zhang, Yogendra Pratap Singh, Miji Yeo, Guotao Deng, Jiaqi Lai, Fei Chen, Ibrahim T. Ozbolat, Yin Yu

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body’s limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

中文翻译:


再生医学器官生物打印研究进展



由于身体的再生能力有限,受伤、疾病和衰老引起的器官损伤或衰竭构成了挑战。器官移植存在供体短缺和免疫排斥风险的问题,需要创新的解决方案。按需器官的三维 (3D) 生物打印为组织工程和再生医学带来了希望。在这篇综述中,我们探讨了最先进的生物打印技术,重点是生物墨水和细胞类型的选择。随后,我们讨论了实体器官(如心脏、肝脏、肾脏和胰腺)的生物打印进展,强调了血管形成和细胞整合的重要性。最后,我们提供了对生物打印器官临床转化及其大规模生产背景下的主要挑战和未来方向的见解。
更新日期:2024-06-14
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