Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become a critical strategy for cancer treatment. PANoptosis, a newly discovered form of regulated cell death, integrates key molecular components of pyroptosis, apoptosis, and necroptosis, activating these three death pathways simultaneously to achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits cancer cell growth and resistance, making tumor‐specific induction of PANoptosis a potential cancer therapeutic strategy. Currently, cancer treatment research related to PANoptosis is mainly focused on the development of small molecules and cytokines. However, these approaches still face limitations in terms of metabolic stability and tumor specificity. The development of nanotechnology offers new opportunities for cancer treatment by improving targeting efficiency, extending circulation time, and enhancing therapeutic efficacy and safety. Additionally, the unique physicochemical properties of nanomaterials can effectively optimize PANoptosis induction strategies, establishing nanomaterials as ideal candidates for inducing PANoptosis in tumor cells. This review summarizes the concept and mechanisms of PANoptosis, highlights the latest applications of nanoagents in PANoptosis‐based anti‐cancer therapy, and discusses the challenges and future directions for clinical translation. This review will inspire further exploration and development of PANoptosis‐based cancer treatments, providing new perspectives for researchers in the field

中文翻译：

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纳米材料诱导的细胞凋亡：一种有前途的抗肿瘤策略


恶性肿瘤对全球公共卫生构成重大威胁。促进癌细胞程序性细胞死亡已成为癌症治疗的关键策略。泛细胞凋亡是一种新发现的调节性细胞死亡形式，它整合了焦亡、细胞凋亡和坏死性凋亡的关键分子成分，同时激活这三种死亡途径，以实现协同多机制杀伤。PANoptosis 显着抑制癌细胞生长和耐药性，使 PANoptosis 的肿瘤特异性诱导成为一种潜在的癌症治疗策略。目前，与 PANoptisis 相关的癌症治疗研究主要集中在小分子和细胞因子的开发上。然而，这些方法在代谢稳定性和肿瘤特异性方面仍然存在限制。纳米技术的发展通过提高靶向效率、延长循环时间、增强治疗效果和安全性，为癌症治疗提供了新的机会。此外，纳米材料独特的物理化学性质可以有效优化 PANoptosis 诱导策略，使纳米材料成为诱导肿瘤细胞 PANoptosis 的理想候选者。本文总结了 PANoptosis 的概念和机制，重点介绍了纳米药物在基于 PANoptosis 的抗癌治疗中的最新应用，并讨论了临床转化的挑战和未来方向。这篇综述将激发对基于 PANoptosis 的癌症治疗的进一步探索和开发，为该领域的研究人员提供新的视角