Despite the impressive characteristics of biological metal organic frameworks (bioMOFs) for their use as drug delivery systems (DDs), there are still some parameters related to their structural stability and processing routes that have decelerated their realistic application in this field. Both drawbacks are unraveled in this work for the microporous bioMOF CaSyr-1 by using supercritical CO2 (scCO2) to load the bioMOF with the anti-tubercular isoniazid (INH) drug, and functionalize its external surface with a hydrophobic protective layer of stearate (S). The hydrophobicized CaSyr-1(INH)/S vehicle is further coated with a neutral surfactant (PS60) to enhance the wettability of the system. In vitro tests, related to drug carrier biocompatibility and drug release in body simulated fluids, are performed to demonstrate potential prospective of the designed DDs in pharmacy. The synthetized product displayed total biocompatibility even at high concentrations, and the particle size and dissolution rate showed to be adequate for pulmonary administration.

中文翻译：

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超临界 CO2 辅助 bioMOF 药物包埋和功能化，用于具有协同治疗价值的递送


尽管生物金属有机框架 （bioMOFs） 用作药物递送系统 （DDs） 具有令人印象深刻的特性，但仍有一些与其结构稳定性和加工路线相关的参数减缓了它们在该领域的实际应用。在这项工作中，通过使用超临界 CO2 （scCO2） 向 bioMOF 加载抗结核异烟肼 （INH） 药物，并用硬脂酸酯 （S） 的疏水保护层功能化其外表面，为微孔 bioMOF CaSyr-1 解决了这两个缺点。疏水化的 CaSyr-1（INH）/S 载体进一步涂有中性表面活性剂 （PS60），以增强系统的润湿性。进行与药物载体生物相容性和体内模拟液中药物释放相关的体外测试，以证明设计的 DD 在药房中的潜在前景。即使在高浓度下，合成产物也显示出总的生物相容性，并且粒径和溶出速率显示足以用于肺部给药。