The purpose of this study was to investigate the dosimetric and radiobiological parameters of IMRT and TomoTherapy techniques to determine the best technique for the treatment of prostate cancer. Dynamic IMRT and Helical TomoTherapy (HT) radiotherapy techniques were used for the treatment planning of 10 patients with prostate cancer. Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) based on Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) models as radiobiological parameters in addition to the multiple dosimetrics including Equivalent Uniform Dose (EUD), Heterogeneity Index (HI), and Conformity Index (CI) were evaluated. The mean NTCP value based on the LKB model for the IMRT method was higher than that for the HT method by approximately 4.62% for the bladder and 4.89% for the rectum, respectively. Similarly, in the RS model, the average NTCP values for IMRT were approximately 4.14% and 12.78% for the bladder and rectum, higher than the HT. The mean values of the HI and CI indices in IMRT were obtained as 0.06 ± 0.01 and 1.13 ± 0.08, respectively. With the HT technique, the index values were equal to 0.04 ± 0.01 and 1.09 ± 0.05, respectively. The mean doses to the rectum and right/left femoral heads were 13.19%, 11.32%, and 10.90% higher in IMRT than in HT, respectively. However, the mean dose to the bladder tissue was 17.13% higher in HT than in IMRT. Our study demonstrated that HT plans were superior to IMRT plans in terms of estimated NTCP using radiobiological models (LKB and RS) for healthily tissues. Except for the higher treatment duration, while having a desired and uniform dose distribution to the tumor, the TomoTherapy technique leads to preservation of healthy organs.

中文翻译：

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前列腺癌 TomoTherapy 和 IMRT 计划的剂量学和放射生物学比较


本研究的目的是调查 IMRT 和 TomoTherapy 技术的剂量学和放射生物学参数，以确定治疗前列腺癌的最佳技术。动态 IMRT 和螺旋断层放射治疗 （HT） 放疗技术用于 10 例前列腺癌患者的治疗计划。基于 Lyman-Kutcher-Burman （LKB） 和相对连续性 （RS） 模型作为放射生物学参数的肿瘤控制概率 （TCP） 和正常组织并发症概率 （NTCP） 以及包括等效均匀剂量 （EUD） 、异质性指数 （HI） 和一致性指数 （CI） 在内的多种剂量计量学被评估。基于 LKB 模型，IMRT 方法的平均 NTCP 值比 HT 方法高出约 4.62%，膀胱和直肠分别高约 4.89%。同样，在 RS 模型中，IMRT 的平均 NTCP 值约为 4.14% 和膀胱和直肠的 12.78%，高于 HT。IMRT 中 HI 和 CI 指数的平均值分别为 0.06 ± 0.01 和 1.13 ± 0.08。使用 HT 技术，指数值分别等于 0.04 ± 0.01 和 1.09 ± 0.05。IMRT 对直肠和右/左股骨头的平均剂量分别比 HT 高 13.19% 、 11.32% 和 10.90%。然而，HT 对膀胱组织的平均剂量比 IMRT 高 17.13%。我们的研究表明，在使用放射生物学模型 （LKB 和 RS） 对健康组织估计的 NTCP 方面，HT 计划优于 IMRT 计划。除了更长的治疗持续时间外，在对肿瘤具有理想且均匀的剂量分布的同时，TomoTherapy 技术可以保护健康的器官。