Our study investigates the influence of several doses of gamma rays on the antibacterial behavior of nanocomposite of silver nanoparticles (AgNPs) doped in a blend of poly (vinyl alcohol) (PVA)-Polyvinyl Pyrrolidone (PVP). AgNPs@PVA-PVP nanocomposite films were fabricated via laser ablation route, and then the synthesized films were subjected to various gamma ray's doses. X-ray diffraction (XRD) data shows a diffraction peak at 2θ = 38° assigned to the existence of AgNPs. Ultraviolet–visible (UV–Vis) results confirm the characteristic peak of silver nanoparticles at 425 nm. The cell viability and antibacterial behavior results confirmed the enhancement in the performance of AgNPs@PVA-PVP composite after irradiated to gamma rays. These values of cell viability have been raised by increasing the dose of gamma rays to 94.5 ± 6.5 % for dose at 70 kGy gamma rays. The values of the inhibition zone of microorganisms were enhanced by raising the doses of gamma rays to 19.5 ± 0.5 and 21.3 ± 0.6 against E. coli and S. aureus respectively specifically for nanocomposite with gamma dose 70 kGy. Thus, the improved antibacterial activity of AgNPs@PVA-PVP nanocomposite could be used in biomedical applications.

中文翻译：

---

提高 AgNPs@PVA-PVP 三元纳米复合薄膜的抗菌活性，然后进行伽马射线辐照处理，用于生物医学应用


我们的研究调查了几种剂量的伽马射线对掺杂在聚乙烯醇 （PVA） -聚乙烯吡咯烷酮 （PVP） 混合物中的银纳米颗粒 （AgNPs） 纳米复合材料的抗菌行为的影响。通过激光烧蚀路线制备了 AgNPs@PVA-PVP 纳米复合薄膜，然后对合成的薄膜进行了各种伽马射线剂量的照射。X 射线衍射 （XRD） 数据显示，2θ = 38° 处的衍射峰被认为是 AgNP 的存在。紫外-可见光 （UV-Vis） 结果证实了银纳米颗粒在 425 nm 处的特征峰。细胞活力和抗菌行为结果证实了 AgNPs@PVA-PVP 复合材料在辐照伽马射线后性能的增强。通过将 γ 射线剂量增加到 94.5 ± 6.5 % 的 70 kGy γ 射线剂量，提高了这些细胞活力值。通过将对大肠杆菌和金黄色葡萄球菌的伽马射线剂量分别提高到 19.5 ± 0.5 和 21.3 ± 0.6，特别是对于伽马射线剂量为 70 kGy 的纳米复合材料，微生物的抑制区值得到提高。因此，AgNPs@PVA-PVP 纳米复合材料改进的抗菌活性可用于生物医学应用。