Lead Isotopes can be effectively used in nuclear medicine, 203Pb forms a theranostic pair with 212Pb whereas 201Pb→ 201Tl, facilitate the production of 201Tl via the generator system. The aim of this work was to achieve the high purity production of 203Pb and 201Tl via a cyclotron. To achieve this, several charged particle induced reactions namely 205Tl(p,3n)203Pb, 205Tl(d,4n)203Pb, 205Tl(p,5n)201Pb→201Tl, 205Tl(d,6n)201Pb→201Tl, 203Tl(p,3n)201Pb→201Tl, and 203Tl(d,4n)201Pb→201Tl were evaluated. First the consistency and reliability of the experimental data were ensured by using established nuclear model codes like TALYS 1.9 and EMPIRE 3.2. A robust methodology, based on experimental data and theoretical nuclear models, was used to generate the recommended cross sections for each production route and associated radioisotopic impurities. The thick target yields were calculated for each production route and its corresponding impurity reaction by utilizing the recommended/reference data. Following a thorough analysis and comparison of the evaluated production routes, it was concluded that the most promising options are 205Tl(d,4n)203Pb and 203Tl(p,3n)201Pb→201Tl. Their optimum conditions were determined as Ed = 30 → 21 MeV and Ep = 30 → 21 MeV with integral yields of 568.9 MBq/μAh and 1223.5 MBq/μAh respectively.

中文翻译：

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医用放射性核素 201Pb→201Tl 和 203Pb 回旋加速器产生的横截面数据评估


铅同位素可以有效地用于核医学，203Pb 与 212Pb 形成治疗诊断对，而 201Pb→ 201Tl 则促进通过发生器系统产生 201Tl。这项工作的目的是通过回旋加速器实现 203Pb 和 201Tl 的高纯度生产。为此，评估了几种带电粒子诱导的反应，即 205Tl（p，3n）203Pb、205Tl（d，4n）203Pb、205Tl（p，5n）201Pb→201Tl、205Tl（d，6n）201Pb→201Tl、203Tl（p，3n）201Pb→201Tl 和 203Tl（d，4n）201Pb→201Tl。首先，通过使用 TALYS 1.9 和 EMPIRE 3.2 等已建立的核模型代码来确保实验数据的一致性和可靠性。使用基于实验数据和理论核模型的稳健方法为每条生产路线和相关放射性同位素杂质生成推荐的横截面。利用推荐/参考数据计算每条生产路线及其相应杂质反应的厚目标产量。在对评估的生产路线进行彻底分析和比较后，得出结论，最有前途的选择是 205Tl（d，4n）203Pb 和 203Tl（p，3n）201Pb→201Tl。它们的最佳条件被确定为 Ed = 30 → 21 MeV 和 Ep = 30 → 21 MeV，积分产率分别为 568.9 MBq/μAh 和 1223.5 MBq/μAh。