A new treatment option for women unable to take hormone replacement therapy Up to 80% of women experience vasomotor symptoms, including hot flushes and night sweats, during menopausal transition.1234567 These symptoms can persist for years before and after menopause, substantially impacting quality of life by impairing sleep, mood, and cognitive functioning.23456789101112 Approximately 32-46% of women describe their vasomotor symptoms as moderate to severe and would warrant treatment; studies suggest that the median total length of vasomotor symptoms is 7.4 years.4569 An effective treatment of vasomotor symptoms is hormonal therapy, but this treatment is not appropriate for everyone and only about 10% of women worldwide with vasomotor symptoms report using hormonal therapy.23561011131415 Contraindications to hormonal therapy and concerns for adverse effects with prolonged hormonal therapy use may contribute to its low use.2345679 Non-hormonal alternatives to manage vasomotor symptoms are available but these alternatives are generally considered less efficacious than hormonal therapy.6910111314 Furthermore, before 2023, paroxetine was the …

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绝经期血管舒缩症状的非激素管理


无法接受激素替代疗法的女性的新治疗选择 高达 80% 的女性在更年期过渡期会出现血管舒缩症状，包括潮热和盗汗。1234567 这些症状可以在绝经前后持续数年，通过损害睡眠、情绪和认知功能来严重影响生活质量。23456789101112 大约 32-46% 的女性将她们的血管舒缩症状描述为中度至重度，需要治疗;研究表明，血管舒缩症状的中位总持续时间为 7.4 年。4569 激素疗法是血管舒缩症状的有效治疗方法，但这种疗法并不适合所有人，全世界只有约 10% 的有血管舒缩症状的女性报告使用激素疗法。23561011131415 激素疗法的禁忌症和对长期使用激素疗法的不良反应的担忧可能导致其使用率低。2345679 管理血管舒缩的非激素替代品症状是可用的，但这些替代方案通常被认为不如激素治疗有效.6910111314 此外，在 2023 年之前，帕罗西汀是......