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Transient receptor potential channels in viral infectious diseases: Biological characteristics and regulatory mechanisms
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-11-17 , DOI: 10.1016/j.jare.2024.11.022 Wen-Hui Qi, Na Tang, Zhi-Jing Zhao, Xiao-Qiang Li
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-11-17 , DOI: 10.1016/j.jare.2024.11.022 Wen-Hui Qi, Na Tang, Zhi-Jing Zhao, Xiao-Qiang Li
Viral infectious diseases have long posed a challenge to humanity. In recent decades, transient receptor potential (TRP) channels have emerged as newly investigated cation channels. Increasing evidence suggests that TRP channel-mediated Ca2+ homeostasis disruptions, along with associated pathological changes, are critical factors in the onset and progression of viral infectious diseases. However, the precise roles and mechanisms of TRP channels in these diseases remain to be systematically elucidated.
中文翻译:
病毒感染性疾病中瞬时受体电位通道的生物学特征和调控机制
长期以来,病毒性传染病一直对人类构成挑战。近几十年来,瞬时受体电位 (TRP) 通道已成为新研究的阳离子通道。越来越多的证据表明,TRP 通道介导的 Ca2 + 稳态破坏以及相关的病理变化是病毒性传染病发生和发展的关键因素。然而,TRP 通道在这些疾病中的确切作用和机制仍有待系统阐明。
更新日期:2024-11-17
中文翻译:
病毒感染性疾病中瞬时受体电位通道的生物学特征和调控机制
长期以来,病毒性传染病一直对人类构成挑战。近几十年来,瞬时受体电位 (TRP) 通道已成为新研究的阳离子通道。越来越多的证据表明,TRP 通道介导的 Ca2 + 稳态破坏以及相关的病理变化是病毒性传染病发生和发展的关键因素。然而,TRP 通道在这些疾病中的确切作用和机制仍有待系统阐明。