Rapid and accurate testing of 2,6-dipicolinic acid (DPA) and levofloxacin (LFX) has been attracting much attention due to the fact that the former is an important biomarker of anthrax spores and the latter is a third-generation fluoroquinolone drug and has been recognized as an important environmental pollutant. Herein, we report the preparation of a 13-metal Eu(III) nanomolecular sensor (molecular sizes: 2.0 × 2.4 × 3.2 nm) bearing a new flexible Schiff base ligand for luminescence testing of DPA and LFX with high selectivity and sensitivity. The rapid enhancement of the Eu(III) luminescence of 1 caused by DPA and LFX is expressed by fitting equation I_615nm = k × [C] + a, which can be used to quantitatively detect DPA and LFX concentrations in CH₃CN, fetal calf serum (FCS), and a real drug. The response times of 1 to DPA and LFX are less than ten seconds, with detection limits as low as 3.78 × 10^–2 to 2.71 nM. The test strips containing 1, as well as 1@SA films, can be used to qualitatively detect DPA and LFX by the color changes under the irradiation of UV light.

中文翻译：

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基于高核性 Eu（III） 纳米分子传感器的 2,6-二吡啶酸和左氧氟沙星的定性和定量发光检测


2,6-二犀牛酸 （DPA） 和左氧氟沙星 （LFX） 的快速准确检测备受关注，因为前者是炭疽孢子的重要生物标志物，后者是第三代氟喹诺酮类药物，已被公认为重要的环境污染物。在此，我们报道了 13 金属 Eu（III） 纳米分子传感器（分子大小：2.0 × 2.4 × 3.2 nm）的制备，该传感器带有一种新的柔性希夫碱基配体，用于 DPA 和 LFX 的发光测试，具有高选择性和灵敏度。DPA 和 LFX 引起的 Eu（III） 发光 1 的快速增强由拟合方程 I_615nm = k × [C] + a，可用于定量检测 CH₃CN、胎牛血清 （FCS） 和真实药物中的 DPA 和 LFX 浓度。1 对 DPA 和 LFX 的响应时间小于 10 秒，检测限低至 3.78 × 10^–2 至 2.71 nM。包含 1 和 1@SA 薄膜的试纸可用于通过紫外光照射下的颜色变化定性检测 DPA 和 LFX。