Three novel mixed-ligand Ni(II) complexes were synthesized from 3,5-dihalogenosalicyladehyde-S-methyl isothiosemicarbazone ligand (3,5-dichloro for Complex I, 3,5-dibromo for Complex II, and 3,5-diiodo for Complex III) and diethanolamine. The synthesized compounds were characterized by elemental analysis, FT-IR, UV-Vis and 1H-NMR spectroscopies. Solid-state structures of Complex I and Complex II have been determined by single-crystal X-ray diffraction technique. Both the complexes were found to have distorted square planar geometry, with coordination of azomethine nitrogen, phenolate oxygen, terminal amine of thiosemicarbazone ligand and amine nitrogen of diethanolamine. The cytotoxic effects of the ligands and the complexes were evaluated against two different types of cancer cells (THP-1 human leukaemia monocytic cell line and MDA-MB-231 aggressive breast cancer cell line) and healthy cell (HUVEC Human umbilical vein endothelial cell line) by using MTT method. The findings demonstrated that the chloro-derivatives exhibited better efficacy compared to cisplatin in targeting the monocytic leukemia cell line while displaying reduced toxicity towards healthy cells.

中文翻译：

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二卤代取代硫代氨基脲配体和混合配体 Ni（II） 配合物的合成、细胞毒性、结构性质及比较


由 3,5-二卤代水杨酰亚胺-S-甲基异硫代氨基脲配体（复合物 I 为 3,5-二氯，复合物 II 为 3,5-二溴，复合物 III 为 3,5-二碘）和二乙醇胺合成了三种新型混合配体 Ni（II） 复合物。通过元素分析、FT-IR、UV-Vis 和 1H-NMR 光谱对合成的化合物进行表征。复合物 I 和复合物 II 的固态结构已通过单晶 X 射线衍射技术确定。发现两种配合物都具有扭曲的方形平面几何形状，具有偶氮甲嘧啶氮、酚酸盐氧、硫代氨基脲配体的末端胺和二乙醇胺的胺氮的配位。使用 MTT 方法评价配体和复合物对两种不同类型的癌细胞 （THP-1 人白血病单核细胞系和 MDA-MB-231 侵袭性乳腺癌细胞系） 和健康细胞 （HUVEC 人脐静脉内皮细胞系） 的细胞毒作用。研究结果表明，与顺铂相比，氯衍生物在靶向单核细胞白血病细胞系方面表现出更好的疗效，同时对健康细胞的毒性降低。