It is widely accepted that peptides with enantiomeric configurations would self-assemble into nanostructures with opposite supramolecular chirality. However, in this work, we found that the L-peptide polyphenylalanine F10 (FFFFFFFFFF) and its enantiomer f10 displayed mirror image CD spectra, yet both self-assembled into fibers with exclusive left-handedness, a phenomenon also observed in the other two enantiomeric pairs (F9f and f9F, F5f5 and f5F5). Our work provides new insights into the relationship between the molecular chirality of peptide building blocks and the supramolecular chirality of their self-assemblies.

中文翻译：

---

对映体肽以相同的旋向自组装成原纤维


人们普遍认为，具有对映体构型的肽会自组装成具有相反超分子手性的纳米结构。然而，在这项工作中，我们发现 L 肽多苯丙氨酸 F10 （FFFFFFFFFF） 及其对映异构体 f10 显示出镜像 CD 光谱，但两者都以独特的左旋性自组装成纤维，这种现象也观察到其他两个对映体对（F9f 和 f9F、F5f5 和 f5F5）。我们的工作为肽构建单元的分子手性与其自组装的超分子手性之间的关系提供了新的见解。