A palladium-catalyzed cascade cyclization reaction of di-o-iodophenyl sulfonylguanidines with isocyanides for the efficient and selective synthesis of 5- or 6-membered heterocyclic fused quinazolines has been developed. Diverse functional groups are well tolerated, and this method has been successfully applied to a larger scale synthesis.

中文翻译：

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钯催化的异氰化物与二（邻碘苯基）磺酰胍的级联环化反应：获得杂环稠合喹唑啉


已经开发了一种钯催化的二邻碘苯基磺酰胍与异氰化物的级联环化反应，用于高效和选择性合成 5 元或 6 元杂环稠合喹唑啉。不同的官能团耐受性良好，该方法已成功应用于更大规模的合成。